What is CD40 signaling?
CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death.
What is CD40 in immunology?
Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40.
What is the function of CD40?
CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.
What does CD40 interact with?
CD40L/CD40 interaction in immunity CD40 interacts with CD40L, which is found primarily on activated T cells, playing a role in both humoral and cellular immune responses.
What is a CD40 agonist?
CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma.
Is CD40 a receptor?
CD40L binds to its receptor CD40 on B cells and dendritic cells and thereby provides a critical helper T cell signal needed for germinal centre formation, isotype class switching and production of immunoglobulin antibodies5–8.
What are CD40 on the T cells?
Introduction. CD40L, or CD154, is canonically expressed on CD4+ T cells and it is a principal modulator of a wide range of humoral and cellular immune responses (1, 2). One of the primary functions of CD40L is the T cell-mediated activation of DCs and monocytes (3, 4), in a process known as DC licensing.
What is CD40 antibody?
CD40, a stimulatory receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells, such as macrophages, dendritic cells and various tumor cell types; it plays a key role in the activation of the immune system.
How would Anti CD40 agonistic antibodies increase the immune response to antigens?
Ligation of CD40 on the surface of antigen presenting cells (APC) enhances the expression of MHC and costimulatory molecules such as CD86, stimulates the production of pro-inflammatroy cytokines such as IL-12 and induces T cell activation, all of which are essential to cell-mediated immune responses (1, 3).