Why is cytochrome P450 called mixed-function oxidase?
The name “mixed-function oxidase” indicates that the enzyme oxidizes two different substrate simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction.
How does mixed-function oxidase work?
It is known as a mixed-function oxidase, or monooxygenase, because one oxygen atom from molecular oxygen is incorporated into the product while the other goes on to form water. Cytochrome P450 in the liver, for example, oxidizes and detoxifies many kinds of substances that would otherwise be poisonous.
Where is the primary site of mixed-function oxidase activity in the body?
Mixed function oxidases are present in the proximal tubules and can be selectively induced or inhibited by xenobiotics. Enzyme activity varies between different segments of the nephron.
What is the microsomal mixed-function oxidase system?
The liver microsomal mixed function oxidase system is a multicomponent system consisting of two proteins, cytochrome P-450 and NADPH-cytochrome c reductase and a lipid, phosphatidylcholine.
What is the function of oxidase?
In biochemistry, an oxidase is an enzyme that catalyzes oxidation-reduction reactions, especially one involving dioxygen (O2) as the electron acceptor. In reactions involving donation of a hydrogen atom, oxygen is reduced to water (H2O) or hydrogen peroxide (H2O2).
What is mixed-function oxygenase system?
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases.
What is the function of phosphatidylcholine in Multienzyme mixed-function oxidase system in endoplasmic reticulum?
14. What is the function of Phosphatidylcholine in multienzyme mixed-function oxidase system, located in the endoplasmic reticulum? Explanation: Phosphatidylcholine has choline as a head group. These are major components of the cell membrane.
What are the names of the three protein involved in multi enzyme mixed-function oxidase system located in the endoplasmic reticulum?
3 Heme protein, retinal protein, phosphatidylcholine.
What is mixed function oxygenase system?
What is the function of cytochrome oxidase in the organism?
Cytochrome c oxidase is the terminal complex of eukaryotic oxidative phosphorylation in mitochondria. This process couples the reduction of electron carriers during metabolism to the reduction of molecular oxygen to water and translocation of protons from the internal mitochondrial matrix to the inter-membrane space.
What is meant by oxidase?
Definition of oxidase : any of various enzymes that catalyze oxidations especially : one able to react directly with molecular oxygen.
What is the role of cytochrome oxidase in the production of ATP?
Cytochrome oxidase is a transmembrane molecule found in the mitochondria of eukaryotes and in the cellular space of aerobic prokaryotes. This molecule is a proton pump that plays a vital role in producing energy, in the form of ATP, via the ETS (Figure 3).