Which drugs cause birth defects teratogens?
Teratogenic drugs and birth defects
- ACE (angiotensin converting enzyme) inhibitors.
- angiotensin II antagonist.
- isotretinoin (an acne drug)
- alcohol.
- cocaine.
- high doses of vitamin A.
- lithium.
- male hormones.
Why is propofol contraindicated in pregnancy?
-This drug should not be used for obstetric anesthesia because it crosses the placenta and may be associated with neonatal depression. Animal studies have shown some evidence of delayed ossification or abnormal cranial ossification with an increase in the incidence of subcutaneous hematomas.
Which inhalation anesthetic agents may have teratogenic effect?
Nitrous oxide (N2O) is the only inhalation anaesthetic that has definitely been shown to be teratogenic in experimental animals. Studies to date indicate that there may be many mechanisms contributing to this effect.
Is propofol safe in pregnancy?
Abstract. Propofol has been used for the induction and maintenance of general anesthesia during pregnancy although this is not an indication approved by Zeneca Pharmaceuticals. Compared with thiopentone, propofol reduces the cardiovascular response to laryngoscopy and tracheal intubation.
What are 4 teratogens?
Teratogens are classified into four types: physical agents, metabolic conditions, infection, and finally, drugs and chemicals.
Is succinylcholine safe in pregnancy?
Thus succinylcholine is an ideal neuromuscular blocker in pregnant females because it provides an excellent intubation conditions along with a short duration of apnea, although it has been observed that the duration of action of succinylcholine is significantly longer in pregnant women as compared with nonpregnant …
Is midazolam safe in pregnancy?
Based on this, the US Food and Drug Administration (FDA) has suggested that midazolam be avoided for use as general anesthesia and sedation during the third trimester of pregnancy for surgeries not related to delivery of the baby.
What is use of halothane?
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.
What are teratogens give 5 examples?
Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy.