What type of cancer is dermatofibrosarcoma protuberans?
Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer. It starts in connective tissue cells in the middle layer of the skin (dermis). Dermatofibrosarcoma protuberans might look like a pimple or feel like a rough patch of skin at first.
Is DFSP benign or malignant?
DFSP is a malignant tumor, but only metastasizes 1-4% of the time. Metastasis is a late clinical outcome and typically occurs only after several local recurrences.
Is Dermatofibrosarcoma malignant?
Dermatofibrosarcoma protuberans (DFSP) is a rare dermal malignancy affecting the deep dermis and subcutaneous tissues. It was first reported by Darier and Ferrand in 1924. This tumor is locally aggressive with high recurrence rates, but rarely metastasizes.
Can DFSP be benign?
DFSP is considered an intermediate tumor between a benign dermatofibroma and a frank fibrosarcoma due to the possibility of having distant metastasis and aggressive local invasion.
What is the difference between cancer and sarcoma?
Carcinomas are cancers that develop in epithelial cells, which cover the internal organs and outer surfaces of your body. Sarcomas are cancers that develop in mesenchymal cells, which make up both your bones and soft tissues, such as muscles, tendons, and blood vessels.
Can DFSP cause other cancers?
Specifically, female patients with DFSP were at increased risk of other nonepithelial skin cancer (O:E, 14.50; 95% CI, 3.46-38.98), melanoma (O:E, 2.59; 95% CI, 1.02-5.35), and breast cancer (O:E, 1.44; 95% CI, 1.00-2.00).
How is Dermatofibrosarcoma treated?
Surgical excision remains the mainstay of treatment for dermatofibrosarcoma protuberans (DFSP). Despite controversy, Mohs micrographic surgery has been increasingly accepted as the treatment of choice, while others advocate wide local excision.
Can a dermatofibroma become cancerous?
However, if a person has a growth that looks like a dermatofibroma but is rapidly growing or changing, they should seek medical advice. This growth may be a sign of a rare type of cancer called dermatofibrosarcoma protuberans.
How do you prevent DFSP?
One way to reduce DFSP from returning may be to treat patients with both excision and Mohs surgery. In one small study, the cancer did not return when patients received both excision and Mohs. More research is needed to find out whether this can reduce the risk of DFSP returning.
Can DFSP come back?
Dermatofibrosarcoma protuberans (DFSP) is very rare tumor of dermis layer of skin with the incidence of only 1 case per million per year. DFSP rarely leads to a metastasis (Less than 5% have metastasis), but DFSP can recur locally.