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What is UniProt annotation?

What is UniProt annotation?

Automatic classification and domain annotation UniProt uses InterPro to classify sequences at superfamily, family and subfamily levels and to predict the occurrence of functional domains and important sites.

What is UniProt Knowledgebase?

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation.

What databases can be searched using UniProt?

The UniProt website provides ten main datasets and three main tools. The key UniProt datasets are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), the UniProt Archive (UniParc) and protein sets for completely sequenced genomes (Proteomes).

How many proteins are in UniProt?

UniProt release 2020_04 contains over 189 million sequence records (Figure 1), with >292 000 proteomes, the complete set of proteins believed to be expressed by an organism, originating from completely sequenced viral, bacterial, archaeal and eukaryotic genomes available through the UniProtKB Proteomes portal (https:// …

Why is UniProt important?

UniProt is the central resource for storing and interconnecting information from large and disparate sources, and the most comprehensive catalog of protein sequence and functional annotation.

What is UniProt in bioinformatics?

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).

What is the function of UniProt?

The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.

What are the features of UniProt?


  • High-quality annotation.
  • Manual annotation by curators based on literature and sequence analysis.
  • Automatic classification and annotation.
  • High-quality Automated and Manual Annotation of microbial Proteomes (HAMAP)
  • Standardized nomenclature and controlled vocabularies.

Is Swiss-Prot and UniProt same?

Swiss-Prot (created in 1986) is a high quality manually annotated and non-redundant protein sequence database, which brings together experimental results, computed features and scientific conclusions. UniProtKB/Swiss-Prot is now the reviewed section of the UniProt Knowledgebase.

What is the importance of UniProt?

UniProt facilitates scientific discovery by organizing biological knowledge and enabling researchers to rapidly comprehend complex areas of biology.

What are the major features of UniProt?

What is the difference between UniProt and Swiss-Prot?

Protein families and groups of proteins are continuously reviewed to keep up with current scientific findings. UniProtKB/TrEMBL is a computer-annotated (unreviewed) supplement to Swiss-Prot, which strives to gather all protein sequences that are not yet represented in Swiss-Prot.