What is the difference between CGH and array CGH?
Array CGH is automated, allows greater resolution (down to 100 kb) than traditional CGH as the probes are far smaller than metaphase preparations, requires smaller amounts of DNA, can be targeted to specific chromosomal regions if required and is ordered and therefore faster to analyse, making it far more adaptable to …
Is array CGH same as microarray?
These very small changes are often called microdeletions and microduplications. Array CGH is also sometimes called CGH array, aCGH or simply a microarray.
What is detected by an array of CGH analysis?
Array CGH detects microscopic and submicroscopic deletions and duplications at targeted areas of the genome, including loci of known microdeletion/microduplication syndromes, subtelomeric regions, and pericentromeric regions. Array CGH will also identify marker chromosomes, some cases of mosaicism, and aneuploidy.
What diseases does microarray test for?
Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA).
Can a microarray detect autism?
Blue chips: Microarrays are efficient and accurate at detecting autism variants, but are virtually unknown to most pediatricians and family practice doctors.
How accurate is microarray testing?
Overall, microarray was successful in 98.8% of cases (4340 of 4391). The microarray analysis was performed on uncultured samples for 3860 (87.9%) of the 4391 participants.
In which situation is microarray testing recommended?
Prenatal chromosomal microarray analysis is recommended for a patient with a fetus with one or more major structural abnormalities identified on ultrasonographic examination and who is undergoing invasive prenatal diagnosis. This test typically can replace the need for fetal karyotype.