What is Rifampicin 150 mg used for?
Tuberculosis: Rifampicin, used in combination with other active anti-tuberculosis drugs, is indicated in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifampicin is also effective against most atypical strains of mycobacteria.
What does rifampin do to your body?
Rifampin is an antibiotic that is used to treat or prevent tuberculosis (TB). Rifampin may also be used to reduce certain bacteria in your nose and throat that could cause meningitis or other infections.
What is the best time to take rifampin?
It is important that you do not miss any doses. Take the capsule on an empty stomach, 1 hour before or 2 hours after a meal, with a full of glass water. It is important to take this medicine on a regular schedule. If this medicine upsets your stomach, take it with food.
Can rifampin cause liver damage?
Rifampin is associated with transient and asymptomatic elevations in serum aminotransferase and bilirubin levels and is a well known cause of clinically apparent, acute liver disease that can be severe and even fatal.
What is the most serious complication of rifampin?
A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor. Liver problems have happened with rifampin.
Does rifampin weaken your immune system?
Its antibacterial activity is mediated by the inhibition of bacterial RNA polymerase. There is evidence that rifampin also modulates the host immune response, influencing such functions as lymphocyte migration, cytokine production, antigen presentation, and phagocytosis (9, 14, 17, 21, 31).
Can I drink coffee with rifampin?
You can take your medicine with milk, water, juice, soda, coffee or tea. If your medicine causes upset stomach, you can take it with food. If you are taking an antacid (like Maalox or Mylanta), take it 1 hour before or 2 hours after taking Rifampin.
What is the most serious potential adverse effect of rifampin use?
Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), mental/mood changes (such as confusion, unusual behavior), unusual tiredness, easy bruising/bleeding, small red spots on the skin, joint pain/swelling, new or worsening …
What is a common side effect of rifampin?
Upset stomach, heartburn, nausea, menstrual changes, or headache may occur. If any of these effects last or get worse, inform your doctor promptly. This medication may cause urine, sweat, saliva, or tears to change color (yellow, orange, red, or brown).
How many mg of rifampicin are in a capsule?
Each capsule contains 150 mg rifampicin. Excipients with known effect: Each capsule contains 42 mg of lactose monohydrate. Each capsule contains a trace (0.015 % w/w of the capsule cap) of azorubine. For the full list of excipients, see section 6.1. 3. Pharmaceutical form
What is the chemical name of the antibiotic rifampin?
Rifampin is a semisynthetic antibiotic derivative of rifamycin SV. Rifampin is a red-brown crystalline powder very slightly soluble in water at neutral pH, freely soluble in chloroform, soluble in ethyl acetate and in methanol. Its molecular weight is 822.95 and its chemical formula is C43H58N4O12.
What is the minimum lethal dose of rifampicin?
The minimum acute lethal or toxic dose is not well established. However, nonfatal acute overdoses in adults have been reported with doses ranging from 9 to 12 g rifampicin. Fatal acute overdoses in adults have been reported with doses ranging from 14-60 g. Alcohol or a history of alcohol abuse was involved in some of the fatal and nonfatal reports.
What is the ATC code for rifampicin?
Pharmacological properties Pharmacotherapeutic group: Antimycobacterials, antibiotics, ATC code: J04AB02 Rifampicin is an active bactericidial antituberculosis drug which is particularly active against the rapidly growing extracellular organisms and also has bactericidial activity intracellularly.