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What is indole-3-carbinol used for?

What is indole-3-carbinol used for?

Indole-3-carbinol is a substance found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. It can also be produced in the laboratory. Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer.

Does indole-3-carbinol increase testosterone?

According to our results, several steroid hormones (estradiol, estrone sulphate and androstenedione) were significantly increased in I3C treated tumor homogenates while testosterone was diminished. Interestingly, testosterone was significantly increased in the sera of I3C treated mice.

Are I3C supplements safe?

Doses up to 400 mg daily have been used safely for 3-76 months. It can cause side effects such as skin rashes and diarrhea. In higher doses, indole-3-carbinol can cause balance problems, tremor, and nausea.

Does indole-3-carbinol help with weight loss?

These findings suggest that I3C has a potential benefit in preventing obesity and metabolic disorders, and the action for I3C in vivo may involve multiple mechanisms including decreased adipogenesis and inflammation, along with activated thermogenesis.

Does indole-3-carbinol reduce estrogen?

I3C decreases estrogen-driven luciferase activity. Treatment with genistein results in an even greater decrease. Treatment with the two phytochemicals reduces expression significantly more than would have been predicted if the effect of the two phytochemicals were additive, which indicates a clearly synergistic effect.

Can indole-3-carbinol raise blood pressure?

Dietary administration of the aryl hydrocarbon indole-3-carbinol (I3C) at a dose of 0.15% induces a slowly developing form of ANG II-dependent hypertension, whereas dietary administration of a higher dose (0.3%) of I3C results in the development of ANG II-dependent malignant hypertension.

Does indole 3 carbinol reduce estrogen?

Does DIM help weight loss?

Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect.

Does I3C lower estrogen?

What vegetable has the most indole-3-carbinol?

Which foods contain the most indole-3-carbinol?

  • Garden cress (aka pepper cress) – 8.0mg.
  • Brussels sprouts – 5.6mg.
  • Kale – 1.0mg.
  • Watercress – 1.0mg.
  • Turnips – 1.0mg.
  • Cabbage, green – 1.6mg.
  • Cabbage, red – . 2mg.
  • Broccoli – 1.2mg.

What are the symptoms of high estrogen and low progesterone?

The more frequent fluctuations in estrogen, along with low progesterone are what produce estrogen dominance symptoms: heavy periods, worsened PMS, sleep problems and hot flashes. Overall, perimenopause is a time of low progesterone and high estrogen.

Should DIM be taken at night or morning?

Most people find that taking DIM in the morning with a glass of water and a little food is the best way to go. Some women who have insomnia related to estrogen dominance, perimenopause, or menopause find that taking DIM at night helps them stay asleep longer – and even through the night.