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What is acitretin used for?

What is acitretin used for?

Acitretin is used to treat severe skin disorders, such as psoriasis. It works by allowing normal growth and development of the skin. Acitretin will continue to work after you stop taking it, but after a time, the skin condition returns and you may need to take it again.

What is the difference between isotretinoin and acitretin?

Isotretinoin differs from acitretin and Ro137410 by its striking sebostatic effect in acne after oral, but not topical, administration. The reason for this is not yet understood. Previous studies indicate that cellular retinoic acid binding protein (CRABP) might be implicated in the action of synthetic retinoids.

What is the brand name for acitretin?

Acitretin is a prescription drug. It is available as an oral capsule. It is used in the treatment of psoriasis. It is also available as a brand-name drug called Soriatane and as a generic drug.

Is acitretin any good?

Results/conclusion: Acitretin is an effective systemic therapy for psoriasis and is generally well tolerated at low doses for long-term use. If monotherapy with acitretin is inadequate, it can be used in combination with other treatments, particularly UVB phototherapy, to increase efficacy.

Is acitretin safe to take?

Acitretin may cause bone or muscle problems, including joint pain, muscle pain or stiffness, or difficulty moving. You may get hurt more easily during rough sports. You may also heal more slowly. Acitretin may cause blurred vision or a decrease in night vision (night blindness).

How long can you take acitretin for?

A course of treatment is likely to last for up to six months but occasionally it can be for longer than this. Acitretin is harmful to unborn babies, so it is very important that you do not become pregnant while you are taking it.

How effective is acitretin for psoriasis?

Acitretin is useful for long-term maintenance therapy for plaque psoriasis. In a long-term clinical trial, acitretin was effective for plaque psoriasis with 89% of patients achieving a PASI 50 and 78.4% attaining a PASI 75 after 12 months.

Does acitretin affect immune system?

Acitretin is not immunosuppressive, is generally safe for long-term use and has no time limit restrictions, which makes it useful in combination therapy and for maintenance therapy.

How long should I take acitretin?

An initial daily dose of 25 or 30 mg acitretin (i.e. 1 capsule of Acitretin 25 mg or 3 capsules of Acitretin 10 mg) for 2 to 4 weeks is recommended. After this initial phase, it may be necessary in some cases to increase the dose up to a maximum of 75 mg acitretin per day (i.e. 3 capsules of Acitretin 25 mg).

How long can you be on acitretin?

Does acitretin affect the liver?

Acitretin can also cause clinically apparent liver injury with symptoms and jaundice. Although uncommon, acute liver injury from acitretin is well described and is estimated to occur in 0.1% to 0.5% of treated patients. The onset of injury can be as soon as one week or up to 9 months after starting therapy.