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What does vimentin positive mean?

What does vimentin positive mean?

Mesenchymal and endothelial cells usually stain vimentin positive and thus act as a measure of internal quality control in immunoreactivity. Absence of immunostaining in these areas often indicates that there is significant damage to tissue antigens and loss of structural architecture.

Is melanoma positive for vimentin?

The data showed that high expression of vimentin was significantly associated with melanoma hematogenous metastasis.

What is vimentin in cancer?

Vimentin (VIM) is a type III intermediate filament that maintains cell integrity, and is involved in cell migration, motility and adhesion. When overexpressed in solid cancers, vimentin drives epithelial to mesenchymal transition (EMT) and ultimately, metastasis.

Does vimentin positive mean cancer?

In conclusion, vimentin-positive gastric cancer was associated with the highly invasive phenotype of advanced gastric cancer, especially with scirrhous type of gastric carcinoma. Vimentin may play an important role in the metastasis of gastric carcinoma.

What is vimentin expression?

Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas.

What is vimentin gene?

VIM Gene – Vimentin This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions.

What is vimentin antibody?

Vimentin is a type III intermediate filament protein that plays an essential role in cytoskeletal function and is largely expressed by mesenchymal cells. Human vimentin monomer protein is 466 amino acids in length with theoretical molecular weight of ~54 kDa.

What does vimentin negative mean?

Vimentin expression was semiquantitatively scored as negative (no staining), weak/focal (1–10% positive), intermediate (11–50% positive) and strong (>50%) crisp and intense positive perinuclear band depending on the percentage of positive cells and intensity of staining.

Where is vimentin found?

mesenchymal cells
Vimentin, is a 57kDa class III intermediate filament protein and often found in mesenchymal cells in eukaryotes, or cells that contain a distinct nucleus, and predominately expressed in developing embryo and in cells. Vimentin intermediate filaments are generally present in mesenchymal cells.

Where can vimentin be found?

Vimentin intermediate filaments are generally present in mesenchymal cells. Vimentin is found not only in eukaryotic cells, but also in bacteria, where it helps to form the cytoskeleton. Vimentin is encoded by the VIM gene and has 466 amino acids.

What cells express vimentin?

Vimentin is a widely expressed and highly conserved 57-kD protein that is constitutively expressed in mesenchymal cells, including endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes (3–8).

Is vimentin a mesenchymal marker?

Vimentin is one type of EMT protein marker, which is present in mesenchymal cells and involved in cancer progression [4, 7, 11, 15].