What does the Ras Raf MEK ERK pathway do?
Ras/Raf/MEK/ERK cascade reaction is an important signaling pathway in MAPKs. Various stimuli can activate the corresponding cell surface receptors that, in turn, activates the signal transduction pathway and produce an appropriate biological response (6).
What is the RAF MEK ERK signaling pathway?
The Ras/Raf/MEK/ERK signaling pathway can exert proliferative or antiproliferative effects through downstream transcription factor targets including NF-κB, CREB, Ets-1, AP-1 and c-Myc. ERKs can directly phosphorylate Ets-1, AP-1 and c-Myc, which lead to their activation.
What does the ERK MAPK pathway do?
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
How does MEK activate ERK?
MEK (MAPK/ERK kinase) The two MEK subtypes, MEK1 and MEK2, have molecular weights of 44 and 45 kDa, respectively (74). MEK is a rare dual-specificity kinase that activates ERK by phosphorylating the Tyr and Thr regulatory sites (75).
What is the role of Ras/Raf/MEK/ERK pathway in liver cancer?
The role of Ras/Raf/MEK/ERK pathway in liver cancer Increased expression of Ras/Raf/MEK/ERK kinase in HCC tissue and HCC cells The Ras/Raf/MEK/ERK pathway is important in the pathogenesis of HCC. Firstly, the Ras gene that acted as an upstream component of the signal transduction pathway was mutated in 30% of HCC cases (32).
Is MEK a good target pathway for leukemia treatment?
However, they are presented in this review as Raf and MEK have also been considered as targets in leukemia and this information should be kept in mind when considering targeting this pathway.
How does the Ras/Raf/MEK/ERK pathway contribute to drug resistance?
Furthermore, the Ras/Raf/MEK/ERK pathway can be activated by chemotherapeutic drugs commonly used in leukemia therapy. This review discusses the mechanisms by which abnormal expression of the Ras/Raf/MEK/ERK pathway can contribute to drug resistance as well as resistance to targeted leukemia therapy.
What is the role of Raf/MEK/ERK in the cell cycle?
Steelman LS, Abrams SL, Shelton JG, Chappell WH, Bäsecke J, Stivala F et al. Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle 2010; 9: 1629–1638.