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What does the ABCA1 gene do?

What does the ABCA1 gene do?

The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. The ABCA1 protein is produced in many tissues, with high amounts found in the liver and in immune system cells called macrophages.

What is ABCG1 gene?

ABCG1 (ATP Binding Cassette Subfamily G Member 1) is a Protein Coding gene. Diseases associated with ABCG1 include Tangier Disease and Sitosterolemia. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Regulation of activated PAK-2p34 by proteasome mediated degradation.

What is another name for this membrane protein ABCA1?

cholesterol efflux regulatory protein
ABCA1, also known as cholesterol efflux regulatory protein (CERP), functions as a cholesterol membrane transporter involved in the regulation of cellular cholesterol and phospholipid homeostasis. It has been shown that ABCA1 mediates the traffic of lipids between Golgi and cell membrane.

How do ABC transporters work?

Function. ABC transporters utilize the energy of ATP binding and hydrolysis to transport various substrates across cellular membranes. They are divided into three main functional categories. In prokaryotes, importers mediate the uptake of nutrients into the cell.

What is Tangier’s disease?

Tangier disease is most often characterized by enlarged orange- or yellow-colored tonsils. This discoloration is due to fatty deposits accumulating in the tonsils. Fatty deposits can also form in other organs causing enlargement of the throat, liver, spleen, or lymph nodes.

What is ABCA1 cellular function quizlet?

ABCA1. major determinant of plasma HDL levels. transports cellular cholesterol and phospholipids (mostly phosphatidylcholine) to cell surface-bound apolipoproteins. Helps ApoA1 combine with cholesterol and phospholipids at the plasma membranes of various body cells to produce the discoidal nascent HDL.

What chromosome is the ABCA1 gene on?

Chromosome 9

Gene location (Human)
Chr. Chromosome 9 (human)
Band 9q31.1 Start

Is ABCA1 a lipid transfer protein?

In this review, information is presented to answer the question of whether ABCA1 is a lipid transfer protein. It will become apparent that because the transporter mediates the transfer of PL (and FC) from a cell PM (donor) to apoA-I (acceptor), the simple answer is “yes”.

Who is the owner of ABC transport company?

Frank Nneji (1993–)ABC Transport / CEO

How many types of ABC transporters are there?

There are 48 ABC transporters in humans [8,9] and many of these have been shown to be responsible for or involved in disease states, including cystic fibrosis, Tangier disease, adrenoleukodystrophy, and cancer (see below).

What does Tangier disease do to the body?