What does a positive tissue transglutaminase AB IgA mean?
Interpretation. Positive results for tissue transglutaminase (tTG) IgA antibodies are consistent with a diagnosis for celiac disease and possibly for dermatitis herpetiformis.
What is the normal range for tissue transglutaminase AB IgA?
Table 1.
| ANTIGEN | ANTIBODY TYPE | SENSITIVITY, % (RANGE) |
|---|---|---|
| Gliadin | IgG | 80 (42–100) |
| Endomysium | IgA | 95 (86–100) |
| IgG | 80 (70–90) | |
| Tissue transglutaminase | IgA | 98 (78–100) |
What does it mean if tissue transglutaminase is high?
High Tissue Transglutaminase Antibody Titers Are Diagnostic for Celiac Disease. A tTG titer greater than 10 times the upper limit of normal predicts biopsy findings of celiac disease.
What is transglutaminase IgG AB?
The finding of transglutaminase IgG antibodies may indicate a diagnosis of celiac disease, particularly in individuals who are IgA deficient. For individuals with moderately to strongly positive results, a diagnosis of celiac disease is possible and the patient should undergo a biopsy to confirm the diagnosis.
Does low IgA mean celiac?
What is the Connection between Celiac Disease and IgA Deficiency? An estimated 2% of people with celiac disease also have selective immunoglobulin A (IgA) deficiency. If someone has IgA deficiency and celiac disease, the IgA deficiency can cause a false negative on a celiac disease antibody test.
What is a high celiac number?
Celiac disease. >10.0 U/mL. Normal or elevated IgA.
What is a positive tissue transglutaminase test?
Positive results for tissue transglutaminase (tTG) IgA or IgG antibodies are consistent with a diagnosis for celiac disease and possibly for dermatitis herpetiformis.
Does high IgA mean celiac?
However, 3 percent of patients with celiac disease have IgA deficiency. Therefore, if the serum IgA tTG result is negative but clinical suspicion for the disease is high, a serum total IgA level may be considered. Screening of asymptomatic patients is not recommended.
What is considered a low IgA level?
In general, serum IgA level of less than 7 mg/dL (0.07 g/L) is considered as selective IgA deficiency since this concentration is the lowest detectable limit established by most of the laboratories.
Is low IgA serious?
Most people with selective IgA deficiency are healthy, but some patients experience more frequent or severe infections. Patients with selective IgA deficiency have a slightly higher risk of having allergies (abnormal immune system reactions to environmental substances or food) and asthma (swollen airways in the lungs).
Can celiac cause weight gain?
“Many health care providers don’t recognize the more subtle signs of celiac disease,” Brown explains. “They don’t realize, for example, that celiac disease can cause weight gain as well as weight loss, so they often don’t even consider referring overweight or obese patients for testing.