What does a high Clogp mean?
LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the organic elution solvent like dichloromethane, ethyl acetate or MTBE.
What LogP means?
The Log P value of the compound indicates the permeability of the drugs to reach the target tissue in the body.
What is LogP of a drug?
Definition: A measure of the preference of a compound to dissolve in either water or an organic solvent (such as octanol) when uncharged.
What does LogP 1 mean?
a simple organic compound like octanol or hexane can provide a guideline for predicting its solubility characteristics in other aqueous and organic solvents. For example, a peptide with a measured log P equal to 1 indicates that its concentration is at a 10:1 ratio in organic to aqueous phase.
What is Clogp value?
The logP value of a compound, which is the logarithm of its partition coefficient between n-octanol and water log(coctanol/cwater), is a well established measure of the compound’s hydrophilicity. Low hydrophilicities and therefore high logP values cause poor absorption or permeation.
What is the difference between logP and log D?
LogD is a distribution coefficient widely used to measure the lipophilicity of ionizable compounds, where the partition is a function of the pH. For non-ionizable compounds LogP = LogD throughout pH range, whereas for ionizable compounds LogD takes into account the partition of both ionized and non-ionized forms.
What is logP and logs?
logD is a log of partition of a chemical compound between the lipid and aqueous phases. The most popular lipid phase is octanol. LogP is equivalent to logD for non-ionisable compounds and represents the partition of the neutral form for ionizable compounds (and, hence, is a virtual, unmeasurable, property).
What is the difference between logP and LogD?
How is logP calculated?
Log P calculations are based on a pool of fragments predefined in the log P calculator. This set is based on the data set in Viswanadhan et al. Every fragment is assigned a unique name and a value. The log P value of a molecule is the sum of the fragment values that are present in the molecule.
Is cLogp and logP same?
Most of the time, when we talk about logP values in early drug discovery, we’re talking about cLogp. That “c” stands for calculated. There are several programs that estimate logP based on known values for different rings and functional groups, and with different algorithms for combining and interpolating them.
What is the difference between logD and logP?
What does Clogp measure?