What category is clofibrate?
Clofibrate (trade name Atromid-S) is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL.
Why was clofibrate discontinued?
It was patented in 1958 by Imperial Chemical Industries and approved for medical use in 1963. Clofibrate was discontinued in 2002 due to adverse effects. A PPAR modulator which activates the peroxisome proliferator-activated receptor- alpha . A substance used to lower plasma cholesterol levels.
What is the most common adverse effect of clofibrate?
Common side effects of clofibrate include headache, muscle aches and gastrointestinal upset. Fibrates have multiple drug interactions requiring careful review and use.
What is clofibrate used for?
Clofibrate is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. This may help prevent medical problems caused by such substances clogging the blood vessels.
What is the action of clofibrate?
Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides.
Is tolbutamide still used?
Tolbutamide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
What is the chemical name of clofibrate?
CHEBI:3750 – clofibrate
|Definition||The ethyl ester of clofibric acid.|
|Stars||This entity has been manually annotated by the ChEBI Team.|
|Supplier Information||ChemicalBook:CB5774380, eMolecules:492659, MolPort-000-145-477, Selleckchem:Clofibrate(Atromid-S), ZINC000000056648|
|Download||Molfile XML SDF|
Is clofibrate a prodrug?
This indicates that Compound 1 is a possible prodrug candidate, in that clofibrate is a liquid prodrug that is not very soluble in aqueous media and that generates its active metabolite, clofibric acid, via hydrolysis in vivo.
What class of drug is quinidine?
Quinidine is in a class of medications called antiarrhythmic medications.
What is the drawback of tolbutamide?
This medication can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.
Why is tolbutamide not used?
Tolbutamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).
Why was quinidine discontinued?
Quinidine is no longer widely used for the termination and prevention of arrhythmias because of concern about cardiac and systemic side-effects. This concern was not shared by the patient reported here, who took the drug continuously for 30 years.