What are the 4 subtypes of breast cancer?
Breast cancer has four primary molecular subtypes, defined in large part by hormone receptors (HR) and other types of proteins involved (or not involved) in each cancer: Luminal A or HR+/HER2- (HR-positive/HER2-negative) Luminal B or HR+/HER2+ (HR-positive/HER2-positive) Triple-negative or HR-/HER2- (HR/HER2-negative)
What are the 6 subtypes of triple-negative breast cancer?
performed gene expression profiling of tumor samples from 587 TNBC patients and divided TNBC into six subtypes: basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem-like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR) [13].
How many breast cancer cell lines are there?
We characterized 84 cell lines based on the status of three important receptors conventionally used for breast cancer subtyping, i. e. , estrogen receptor (ER), progesterone receptor (PR), and human epithelial receptor 2 (HER2), and classified them using the same nomenclature, i. e. , luminal A, luminal B, HER2 …
What are triple-negative breast cancer cell lines?
Triple-negative breast cancer (TNBC) represents 10-15% of all breast cancer cases and is defined by the lack of both hormone receptor expression (estrogen and progesterone receptors) and human epidermal growth factor receptor 2 (HER2) amplification/overexpression (3, 4).
What is the most aggressive subtype of breast cancer?
Abstract. Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer and is characteristic of the absence of the expressions of estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 in breast tumor tissues.
Which breast cancer subtype has the best prognosis?
Results: Luminal A was the most commonly diagnosed subtype (59.0%) and had the greatest survival, whereas triple-negative had the poorest survival.
Are there different types of triple-negative breast cancer?
They classified TNBC tumors into the following four distinct subtypes: (1) LAR, (2) mesenchymal (MES), (3) basal-like immunosuppressed (BLIS), and (4) basal-like immune-activated (BLIA).
What are the different types of cell lines?
Cells are classified in 4 different cell type categories based on overall morphology 1) Epithelial 2) Endothelial 3) Neuronal or 4) Fibroblast.
How do I choose a cell line?
The Do’s and Dont’s of Choosing a Cell Line
- Don’t Choose Simply Because It Is Used in the Literature.
- Do Consider If It Fits Your Biological Model.
- Do Consider the Experiments You Want to Perform.
- Table 1: Features of commonly used cell lines.
- Don’t Assume That All Cell Lines Have the Same Culturing Requirements.
What is BT-474 cell line?
BT-474 is a cell line exhibiting epithelial morphology that was isolated from a solid, invasive ductal carcinoma of the breast obtained from a 60-year-old, White, female breast cancer patient. Use these cells in your cancer research.
What causes triple negative breast cancer?
What causes triple negative breast cancer? Researchers don’t know what causes TNBC, but they think BRCA1 genetic mutation might play a part. The BRCA1 gene is meant to prevent cancer. When it mutates, however, the gene reverses course and makes your cells more vulnerable to cancer.
What are the primary features used for breast cancer cell line subtyping?
The status on ER, PR and HER2 are the primary features used for breast cancer cell line subtyping 1, 5, 6, 8, 10, 12, 15, 19, 25, 36, 37, 48, 49, 57-63.
What is a molecular subtype of breast cancer?
The molecular subtype of an invasive breast cancer is based on the genes the cancer cells express, which control how the cells behave. Researchers use molecular subtype information when developing treatment standards of care and when developing new treatments.
By analyzing the molecular features of 92 breast cancer cell lines as documented by different literatures, we categorize 84 cell lines into 5 groups to be consistent with breast tumor classification.
Are breast tumor cell lines a good model for breast cancer heterogeneity?
We conclude that breast tumor cell lines, though having a high mutational frequency with many uncertainties and could not fully capture breast cancer heterogeneity, are feasible but crude models for tumors of the same subtype.