Is Tham an acid or base?
Tham Solution (tromethamine injection) is a sterile, non- pyrogenic 0.3 M solution of tromethamine, adjusted to a pH of approximately 8.6 with glacial acetic acid.
What is severe metabolic acidosis?
Metabolic acidosis develops when too much acid is produced in the body. It can also occur when the kidneys cannot remove enough acid from the body.
What causes metabolic acidosis?
Metabolic acidosis is caused by a build-up of too many acids in the blood. This happens when your kidneys are unable to remove enough acid from your blood.
Is THAM still available?
THAM has been discontinued by the manufacturer with no future production dates planned. THAM has no therapeutic equivalents. Other agents have been developed and researched, but none have ever come to market. Sodium bicarbonate is still currently the most frequently used alkali therapy.
What is THAM used for?
Tham Solution (tromeThamine injection) is indicated for the prevention and correction of metabolic acidosis. In the following conditions it may help to sustain vital functions and thus provide time for treatment of the primary disease: Metabolic Acidosis Associated with Cardiac Bypass Surgery.
What is the best treatment for metabolic acidosis?
Intravenous (IV) treatment with a base called sodium bicarbonate is one way to balance acids in the blood. It ‘s used to treat conditions that cause acidosis through bicarbonate (base) loss.
What are signs of acidosis?
People with metabolic acidosis often have nausea, vomiting, and fatigue and may breathe faster and deeper than normal. People with respiratory acidosis often have headache and confusion, and breathing may appear shallow, slow, or both. Tests on blood samples typically show pH below the normal range.
What drugs cause metabolic acidosis?
The most common drugs and chemicals that induce the anion gap type of acidosis are biguanides, alcohols, polyhydric sugars, salicylates, cyanide and carbon monoxide.
What is Tham used for?
When was Tham discontinued?
It was just recently discontinued by the only manufacturer, Pfizer (Hospira), in the United States as of May 2016. In patients with severe acidosis, alkali therapy is often used to prevent or reverse the detrimental consequences.
What is THAM in medicine?
Tham Solution (tromethamine injection) is indicated for the prevention and correction of metabolic acidosis. In the following conditions it may help to sustain vital functions and thus provide time for treatment of the primary disease: Metabolic Acidosis Associated With Cardiac Bypass Surgery.
Can acidosis be reversed?
Metabolic acidosis can be reversed by treating the underlying condition or by replacing the bicarbonate. The decision to give bicarbonate should be based upon the pathophysiology of the specific acidosis, the clinical state of the patient, and the degree of acidosis.