Is Arimidex more effective than tamoxifen?
Earlier ATAC results found that Arimidex was more effective than tamoxifen in reducing the risk of recurrence of early-stage, hormone-receptor-positive breast cancer in postmenopausal women. Other studies comparing tamoxifen to the other two aromatase inhibitors (Aromasin and Femara) have shown similar results.
Is tamoxifen the same as Arimidex?
Arimidex and tamoxifen belong to different drug classes. Arimidex is a nonsteroidal aromatase inhibitor and tamoxifen is a nonsteroidal antiestrogen. Brand names for tamoxifen include Nolvadex and Soltamox, Nolvadex.
Which has worse side effects tamoxifen or anastrozole?
“Tamoxifen significantly increased the severity of vasomotor symptoms, bladder control, and gynecologic symptoms compared with anastrozole, while anastrozole-treated patients had significantly increased severity of musculoskeletal and vaginal symptoms compared to tamoxifen.
Which is better aromatase inhibitor or tamoxifen?
For women with early-stage oestrogen receptor (ER)-positive breast cancer, adjuvant tamoxifen reduces 15-year breast cancer mortality by a third. Aromatase inhibitors are more effective than tamoxifen in postmenopausal women but are ineffective in premenopausal women when used without ovarian suppression.
Why was anastrozole recalled?
According to the June 26, 2019, US Food and Drug Administration (FDA) Enforcement Report, the recall was initiated due to the potential for cross-contamination from a cleaning procedure failure. The recall affects anastrozole tablets from lots 175289A, 175286B, and 175290B (Exp.
How much does Arimidex increase survival?
Disease-free survival rates were: 71.1% for women treated with an additional 2 years of Arimidex. 70.3% for women treated with an additional 5 years of Arimidex.
Which aromatase inhibitor is best?
In addition to being the most potent non-steroidal AI, letrozole is the only AI that has demonstrated superior efficacy in both the neoadjuvant and adjuvant settings compared with tamoxifen.
Why you should not take tamoxifen?
Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.
What are the long term side effects of Arimidex?
Examples of the long-term side effects of Arimidex include:
- osteoporosis (bone weakness) or bone fractures.
- depression.
- increased cholesterol levels.
- liver problems.
- hair loss or hair thinning.
When should I switch from tamoxifen to aromatase inhibitors?
Most women should take adjuvant hormonal therapy for a total of 5 years. Options include: taking the same hormonal therapy for all 5 years (monotherapy) taking tamoxifen for 2 or 3 years and then switching to an aromatase inhibitor until hormonal therapy has been taken for a total of 5 years (sequential therapy)
Which is the most effective aromatase inhibitor?
In an early report, exemestane was significantly better than tamoxifen in response rate and median time to progression, with overall survival data not yet available. To date, letrozole appears to be the most effective aromatase inhibitor in the first-line advanced breast cancer setting.
Can anastrozole cause memory problems?
The results showed that women who received anastrozole had poorer verbal and visual learning and memory than women who received tamoxifen.