Does Topamax increase liver enzymes?
The patient had some elevation of liver enzyme at baseline during the current admission [Table 1]; hence, as a routine treatment plan, liver function tests (LFTs) were repeated on the 3rd day of starting topiramate. The laboratory results revealed that the liver enzymes increased three times from the baseline.
How does topiramate work for alcoholism?
It has been hypothesized that topiramate may work by reducing dopamine release in reward-related regions of the brain when alcohol is consumed, or individuals are exposed to alcohol cues.
Can you drink alcohol while taking Topamax?
The manufacturing information for Topamax warns, “Do not drink alcohol while taking Topamax. Topamax and alcohol can affect each other, causing side effects such as sleepiness and dizziness.”
How is topiramate metabolized?
Metabolism and Excretion Topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine (approximately 70% of an administered dose). Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose.
What is the connection between Topamax and alcohol?
Topamax interests with GABA inhibitory neurotransmitters to decrease the amount of dopamine released. The result is taking topiramate and alcohol leaves the user with a less pleasurable feeling. Topamax is not the only drug used in the treatment of alcohol dependence that is not fully understood. The acamprosate mechanism of action is also unknown.
Can Topamax cause metabolic acidosis?
Metabolic Acidosis. Topamax® can cause hyperchloremic, non-anion gap, metabolic acidosis (i.e., decreased serum bicarbonate below the normal reference range in the absence of chronic respiratory alkalosis). This metabolic acidosis is caused by renal bicarbonate loss due to carbonic anhydrase inhibition by Topamax®.
What is Topamax and how does it work?
Basically, Topamax works by exerting a similar effect on GABA and glutamate receptors as alcohol, thereby lessening withdrawal symptoms, while also reducing the dopamine-reinforcement effects of drinking behavior.
How long should I take Topamax for alcohol withdrawal?
Topamax for alcohol withdrawal should only be taken as long as it is needed to manage symptoms – typically less than a week – to avoid dependence. There is no standard dosage of Topamax for alcohol addiction; only a doctor can determine this depending on your situation. Only take Topamax under the supervision of a doctor.