Does guaifenesin have a chiral center?
Abstract. The solubility of 3-(2-methoxyphenoxy)-propane-1,2-diol, the well-known chiral drug guaifenesin 1, in water has been investigated by means of polythermal and isothermal approaches. It was found that the solubilities of racemic and enantiomeric diols rac- and (R)-1 depend strongly on temperature.
What is the prototype for guaifenesin?
Codeine/guaifenesin (Robitussin AC) The prototype antitussive, codeine, has been used successfully in some chronic cough and induced-cough models, but scant clinical data exist for upper respiratory tract infections.
What is the mechanism of action of guaifenesin?
Mechanism of Action Guaifenesin loosens and thins phlegm and bronchial secretions to ease expectoration. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
What functional groups are present in dextromethorphan?
Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Is guaifenesin acidic or basic?
The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing….3D Structure for HMDB0004998 (Guaifenesin)
| Property | Value | Source |
|---|---|---|
| pKa (Strongest Acidic) | 13.62 | ChemAxon |
| pKa (Strongest Basic) | -3 | ChemAxon |
| Physiological Charge | 0 | ChemAxon |
How do you synthesize guaifenesin?
Generally, guaifenesin is synthesized by Williamson’s etherification reaction in which nucleophile of guaiacol attacks on glycidol, epichlorohydrin, 1-chloroglycerol, glycerol carbonate, 3-bromo-1-propene and isopropylidene glycerol [21], [22], [23], [24], [25], [26].
What is the prototype name for expectorant?
Guaifenesin (Robitussin) is a widely used and popular expectorant….Expectorant Drugs.
| Prototype Drug | Related Drugs | Drug Classification |
|---|---|---|
| guaifenesin (Robitussin, others) | There are no related drugs at this time | Expectorants |
What is the mechanism of action of mucolytics?
Mucolytics are drugs belonging to the class of mucoactive agents. They exert their effect on the mucus layer lining the respiratory tract with the motive of enhancing its clearance. Mucus is the first line of defense for the various epithelia inside our body against harmful pathogens.
How does guaifenesin metabolized?
Guaifenesin appears to undergo both oxidation and demethylation. The drug is rapidly metabolized in the liver via oxidation to β-(2-methoxyphenoxy)-lactic acid [21].
Is guaifenesin anticholinergic?
Antihistamines (applies to guaifenesin/phenylephrine/pyrilamine) anticholinergic effects. Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive.
What is guaifenesin and dextromethorphan?
DEXTROMETHORPHAN; GUAIFENESIN (dex troe meth OR fan; gwye FEN e sin) is a combination of a cough suppressant and expectorant. It is used for the temporary relief of coughs. This medicine is also used to loosen mucus.
What class is dextromethorphan?
Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing.