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Can Lipitor cause PMR?

Can Lipitor cause PMR?

Three case reports suggested that statin use can trigger the development of polymyalgia rheumatica (PMR) [9]–[11]. PMR is an inflammatory rheumatic disease predominantly seen in the elderly and characterised by muscle pain and morning stiffness in the neck, shoulders, and/or pelvic girdle [13], [14].

Can statins trigger an autoimmune disease?

Although statins are generally considered safe, recent data from long-term follow-up on patients who are on statins for long duration suggest that prolonged exposure to statins may trigger autoimmune reactions.

Should lupus patients take statins?

Statins are a cornerstone, first-line therapy for the prevention and treatment of cardiovascular disease (CVD). But a new study led by researchers from NYU Long Island School of Medicine shows them to be ineffective in patients with the autoimmune disease lupus.

Can Lipitor cause lupus?

An increasing number of cases of statin-induced lupus like syndrome have recently been reported [2–4]. Most cases were caused by second-generation statins, such as simvastatin and atorvastatin.

Does Lipitor destroy muscle?

The side effects most commonly associated with statin use involve muscle cramping, soreness, fatigue, weakness, and, in rare cases, rapid muscle breakdown that can lead to death.

Which statin is least likely to cause muscle pain?

Is muscle pain a side effect of all statins? Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.

What are the long term side effects of Lipitor?

What are statin side effects?

  • Muscle pain and damage. One of the most common complaints of people taking statins is muscle pain.
  • Liver damage. Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation.
  • Increased blood sugar or type 2 diabetes.
  • Neurological side effects.

Which is better Lipitor or Crestor?

Both Lipitor and Crestor are excellent medications to help improve high cholesterol and to decrease your risk of heart attacks and strokes. In studies, Crestor was more effective at lowering total cholesterol levels and raising HDL levels (Jones, 2003).

Why you should not take Lipitor?

“Lipitor can cause serious muscle problems that can lead to kidney problems, including kidney failure,” according to the drug label. “You have a higher chance for muscle problems if you are taking certain other medicines with Lipitor.”

Do statins shorten your life?

A controversial new study found that high cholesterol does not shorten life span and that statins are essentially a “waste of time,” according to one of the researchers. Previous studies have linked statins with an increased risk of diabetes.

Are Statins more commonly reported in patients with PMR?

Overall, statins were more often reported in patients with PMR in comparison with patients who had experienced other ADRs (adjusted ROR 14.21 [95% CI 9.89–20.85]; P = 0.001).

What are the side effects of Lipitor?

In rare cases, Lipitor can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

What are your experiences with Lipitor and Pravachol?

First is that of my wife who experienced a severe case of polymyalgia rheumatica as a consequence of taking Pravachol. Second is my own case of an episode of cardiac arrhythmia lasting a month and unquestionably related to Lipitor. I have a feeling that many other episodes of an untoward nature are occurring and not being reported by my colleagues.

What is PMR in the elderly?

PMR is an inflammatory rheumatic disease predominantly seen in the elderly and characterised by muscle pain and morning stiffness in the neck, shoulders, and/or pelvic girdle [13], [14]. The association between statin use and PMR has not yet been studied in depth.