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Can cisplatin be given before gemcitabine?

Can cisplatin be given before gemcitabine?

Recently, we described that the schedule in which cisplatin was administered 24 hours before gemcitabine produced the best pharmacological profile. Based on this and because toxicity was manageable, the schedule cisplatin 24 hours prior to gemcitabine was chosen for phase II evaluation.

How many cycles of gemcitabine and cisplatin can you have?

You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.

Why is Gemzar given before cisplatin?

The recommendation to administer gemcitabine prior to cisplatin is based on results of phase 1 studies in adults with solid tumors, which indicated that this administration schedule may increase the generation of platinum-DNA adducts (potentially increasing efficacy) and reduce neutropenia.

How effective is gemcitabine and cisplatin?

Median time to progression was 28 weeks and median overall survival was 42 weeks. Toxicity was easily manageable, and no treatment-related deaths occurred. We conclude that gemcitabine in combination with cisplatin may be one of the most effective therapies for patients with advanced gallbladder cancer.

How do you give gemcitabine cisplatin?

Every 21-Day Regimen Schedule

  1. Gemcitabine I.V. infusion over 30 minutes on Days 1 and 8.
  2. Cisplatin I.V. infusion over 1 hour on Day 2 (or Day 1, if recommended by your Doctor)

Does cisplatin need a central line?

Cisplatin is given into a vein (intravenously). You may have the chemotherapy drugs through: a cannula – a short, thin tube the nurse puts into a vein in your arm or hand. a central line – a fine tube that goes under the skin of your chest and into a vein close by.

How long does it take to get cisplatin out of your system?

The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.

How long can you take gemcitabine?

You usually have gemcitabine as a course of several cycles of treatment. This means that you have the drug and then a rest to allow your body to recover. Usually a cycle of gemcitabine is over 3 to 4 weeks (21 to 28 days). You usually have gemcitabine once a week for 2 or 3 weeks and then a week with no treatment.

What is the most common side effect of cisplatin?

The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.

What is gemcitabine plus cisplatin?

Interpretation. Gemcitabine plus cisplatin prolongs progression-free survival in patients with recurrent or metastatic nasopharyngeal carcinoma. The results establish gemcitabine plus cisplatin as the standard first-line treatment option for this population.

How long is cisplatin infusion?

The cisplatin solution for infusion prepared according to instructions (see section 6.6.) should be administered by intravenous infusion over a period of 6 to 8 hours.

Where are chemo ports placed?

Where is a chemo port implanted? Usually, a chemo port is centrally placed under the skin near a large vein in the upper chest. This can be a good alternative to an intravenous (IV) catheter that is peripherally placed in an arm or hand vein (a suitable IV site can sometimes be difficult to find).