How many ovarian cancer cell lines are there?
Worldwide, there are about 100 ovarian cancer cell lines generated as described in literature [12]–[17] and about 70 of these are available at ATCC, ECACC, RIKEN, DSMZ, JCRB or Cancer Research Technology.
What is ovarian cancer cell line?
SK-OV-3 is a human ovarian cancer cell line with epithelial-like morphology. These cells are resistant to tumor necrosis factor and to other cytotoxic drugs such as diphtheria toxin, cisplatin, and adriamycin. The SK-OV-3 cell line forms colonies in soft agar, which serves as a surrogate assay for tumorigenicity.
What types of ovarian cancer are there?
There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. Each has different characteristics and traits: About 85% to 90% of these cancers start in the cells that cover the outer surface of the ovary.
What is A2780 cell line?
A2780 is an ovarian cancer cell line that was established from an Ovarian endometroid adenocarcinoma tumour in an untreated patient. It was deposited with ECACC by Dr T H Ward, from the Cell Culture Unit of the Patterson Laboratories, at the Christie Hospital in Manchester.
What are ID8 cells?
ID8 is one of 10 clonal lines established from late passaged C57BL/6 murine ovarian surface epithelial cells (MOSEC) . Intraperitoneal injection of each of the 10 clonal lines into C57BL/6 mice resulted in formation of peritoneal tumors and ascitic fluid. Of the 10 clonal lines, ID8 exhibited the highest tumor load.
What is the rarest type of ovarian cancer?
Stromal cell ovarian cancer, which arises from connective tissue cells, is very rare. Small cell carcinoma (SCCO) of the ovary is an extremely rare ovarian cancer and it is not certain whether the cells in SCCO are from ovarian epithelial cells, sex-cord stromal cells or germ cells.
What are HEK293T cells?
HEK293T cells are a popular derivative of the original HEK293 parent cell line. The HEK293T genome contains the SV40 large T antigen, which enables them to produce recombinant proteins within plasmid vectors containing the SV40 promoter. For this reason, HEK293T is commonly used for retroviral production.
Which cancers are treated with cisplatin?
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.