What is ERG in prostate cancer?
TMPRSS2-ERG is a high-frequency fusion gene expressed in prostate cancer and plays a vital role in carcinogenesis. Recent studies showed that TMPRSS2-ERG is a potential predictive biomarker for prostate cancer.
What is ERG oncogene?
ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
What is ERG overexpression?
95. The overexpression of ERG is one of the key factors in transforming localised, aggressive cancer into metastatic cancer. 96. High levels of ERG are implicated in loss of cell polarity, changes in cell adhesion, nuclear pleomorphism promoting hyperplasia and PIN in mouse prostate epithelia.
What is TMPRSS2 ERG?
TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8).
What is ERG in biology?
ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG’s oncogenic potential is well known because of its involvement in Ewing’s sarcoma and leukaemia.
What is an erg radiation?
The erg (symbol, erg, i.e. the same as the unit) is the unit of energy in the cgs system, where one erg represents the work done when a force of one dyne is acting over a distance of one cm and is equivalent to 1 x 10-7 joules.
What does an erg do?
An Employee Resource Group (ERG) is a network within a company where employees meet up (in person or remotely) based on shared characteristics, experiences or goals. The groups offer a chance to network and socialize, work on professional development, and to raise awareness of relevant issues.
Why are ERGs used?
Put simply: the purpose of an ERG is to create a safe, supportive space for employees who share a common identity. Underrepresented employees support one another in building their community.
What is erg stand for?
It’s an acronym you should know. ERG stands for employee resource group. Other lesser used terms include affinity groups or business networking groups. Current groups offer much more than mere professional networking opportunities. ERGs can be found in 90% of Fortune 500 companies.
How is an ERG performed?
ERGs are often recorded using a thin fiber electrode that is placed in contact with the cornea or an electrode that is embedded within a corneal contact lens. These electrodes permit the electrical activity generated by the retina to be recorded at the corneal surface.
Why are ERGs so important?
ERGs support learning and development by offering formal and informal leadership opportunities and creating visibility for employees who are active. ERGs also provide a resource for leadership and decision-makers regarding staff/community issues, needs and policies.