Where are Sulfotransferases found?
the Golgi
PAPS is a cosubstrate and source of activated sulfate for both cytosolic sulfotransferases and carbohydrate sulfotransferases, which are located in the Golgi.
What is the function of Sulfotransferase?
Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to an acceptor group of numerous substrates.
What is SULT enzyme?
The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate conjugation of several pharmacologically important endo- and xenobiotics. SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and p-nitrophenol (PNP).
What is sulfation in biology?
Sulfation is an important pathway of metabolism for a range of endogenous compounds including steroid hormones, bile acids, neurotransmitters, and small peptides. Xenobiotics also undergo conjugation by sulfation, which generally, but not exclusively, leads to reduced biological activity.
What is the cofactor for Sult?
The formation of the latter species is catalyzed by sulfotransferases (SULTs), which for their activity depend on the cofactor 3′-phosphoadenosine-5′-phosphosulfate (PAPS).
What causes sulfation?
Sulfation occurs when a battery is deprived of a full charge, it builds up and remains on battery plates. When too much sulfation occurs, it can impede the chemical to electrical conversion and greatly impact battery performance.
What is sulfation process?
sulfation, also spelled Sulphation, in chemistry, any of several methods by which esters or salts of sulfuric acid (sulfates) are formed. The esters are commonly prepared by treating an alcohol with sulfuric acid, sulfur trioxide, chlorosulfuric acid, or sulfamic acid.
What is glucuronidation metabolism?
n. a metabolic process by which drugs or other substances are combined with glucuronic acid to form more water-soluble compounds, which are more readily excreted by the kidneys or in bile. Glucuronidation is the most prevalent of the Phase II reactions of drug metabolism.