What is in a bag of Zosyn?
Each ZOSYN 4.5 g vial provides piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam. Each ZOSYN 40.5 g pharmacy bulk vial contains piperacillin sodium equivalent to 36 grams of piperacillin and tazobactam sodium equivalent to 4.5 grams tazobactam.
What is Zosyn reconstituted with?
2.6 Reconstitution and Dilution of ZOSYN for Injection
| Strength per Pharmacy Bulk Vial | Volume of Diluent to be Added to the Vial | Concentration of the Reconstituted Product |
|---|---|---|
| 40.5 g (36 g piperacillin /4.5 g tazobactam) | 152 mL | 225 mg/mL (200 mg/mL piperacillin/25 mg/mL tazobactam) |
How long can Zosyn be reconstituted?
Stability studies in the I.V. bags have demonstrated chemical stability (potency, pH of reconstituted solution and clarity of solution) for up to 24 hours at room temperature and up to one week at refrigerated temperature. ZOSYN contains no preservatives.
How do you reconstitute Piperacillin and Tazobactam?
The reconstituted solution should be further diluted to at least 50ml with one of the reconstitution diluents, or with Dextrose 5% in Water. Each gram of Piperacillin/Tazobactam 4 g/0.5 g Powder for Solution for Infusion has a displacement volume of 0.7ml.
Why do you infuse Zosyn over 4 hours?
Summary: EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced mortality …
Can vancomycin and Zosyn run together?
Conclusions: A combination of vancomycin 10 mg/mL and piperacillin/tazobactam 112.5 mg/mL demonstrated precipitation immediately upon mixing. Co-infusion of vancomycin and piperacillin/tazobactam via Y-site should be considered incompatible.
Can you mix Zosyn with NS?
Zosyn should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established. Zosyn is not chemically stable in solutions that contain only sodium bicarbonate and solutions that significantly alter the pH.
How do you prepare piperacillin?
Check drug, dose and exp d Wash hands th h Ensure preparation area s Swab top of vial with a sterile alcohol wipe and allow to dry for on Take ampoule(s) of water for injections a e Using 20ml syringe and green needle withdraw 20ml water for in e Inject 20ml of water for injections into vial of Piperacillin/Tazobactam …
Can Zosyn be mixed in d5?
What is ZOSYN extended infusion?
PURPOSE. To develop an extended infusion (EI) protocol for inpatients receiving piperacillin/tazobactam with the goal of decreasing the dose of antibiotic needed to achieve equivalent or superior therapeutic target compared to standard short infusion (SI).
Is ZOSYN used for pneumonia?
Piperacillin and tazobactam is a combination penicillin antibiotic that is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.
Why is Zosyn given over 4 hours?