What is IGF-1 and IGF2?
In mammals, IGF1 is preferentially expressed after birth and is produced almost exclusively in the liver. IGF2 is preferentially expressed in early embryonic and fetal development in a wide variety of somatic tissues.
Whats is IGF?
IGF is a hormone that your body makes naturally. It used to be known as somatomedin. IGF, which comes mainly from the liver, acts a lot like insulin. IGF helps to control growth hormone secretion in the pituitary gland. IGF works with growth hormones to promote growth and development of bone and tissue.
What is recombinant IGF-1?
Human Recombinant IGF-I Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling.
What does IGF target?
Insulin-like growth factor (IGF) signaling plays an important role in regulating growth and development in normal human tissues by promoting cellular proliferation and differentiation and preventing apoptosis [1, 2].
What does IGF2 do?
The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth. Studies suggest that insulin-like growth factor 2 promotes the growth and division (proliferation) of cells in many different tissues.
What causes high IGF2?
IGF2 can be produced in excess by tumour cells because of loss of imprinting (LOI) of the IGF2 gene. IGF2 produced by tumour cells can act in an autocrine manner by binding to isoform A of the insulin receptor (IR-A). This results in stimulation of mitosis and continued production of IGF2.
Is IGF safe?
The World Anti-Doping Agency (WADA) has banned all forms of IGF, including supplements. It says prescription IGF can permanently damage your joints, liver, and heart. OTC supplements aren’t regulated, so there’s no telling what’s in them. Other people take IGF for anti-aging or overall health.
Can IGF-1 cause diabetes?
Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.
What does IGF-2 do?
What are the symptoms of low growth hormone?
A person who has too little adult growth hormone will have symptoms that include:
- A higher level of body fat, especially around the waist.
- Anxiety and depression.
- Decreased sexual function and interest.
- Fatigue.
- Feelings of being isolated from other people.
- Greater sensitivity to heat and cold.
- Less muscle (lean body mass)
What stimulates insulin-like growth factor?
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes.
Where is IGF2 produced?
In contrast with IGF1 (147440), which is preferentially expressed after birth and is produced almost exclusively in liver, IGF2 is preferentially expressed in early embryonic and fetal development and in a wide variety of somatic tissues.