What is b2 glycoprotein I IgM AB?
Clinical Information Beta-2 glycoprotein 1 (beta-2 GP1, also called apolipoprotein H) is a 326-amino acid polypeptide synthesized by hepatocytes, endothelial cells, and trophoblast cells. It contains 5 homologous domains of approximately 60 amino acids each.
What is normal range of beta 2 glycoprotein antibodies?
Normal: β2 GPI IgG ≤ 20 SGU U/mL. β2 GPI IgM ≤ 20 SMU U/mL.
What does a high beta 2 glycoprotein IgM mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What does b2 glycoprotein test for?
Beta-2 glycoprotein 1 antibody tests are primarily used along with cardiolipin antibody and lupus anticoagulant testing to help diagnose: Antiphospholipid syndrome (APS) The cause of an unexplained blood clot (thrombotic episode) The cause of recurrent miscarriages in women.
What is b2 glycoprotein IgG IgM?
Beta-2-Glycoprotein 1 IgG/IgM test is an ELISA (Enzyme-linked immune sorbent assay) test that pits the IgG and IgM antibodies to fight against the beta-2-glycoprotein, present in serum and plasma.
What causes beta 2 glycoprotein?
Beta 2 GP1 antibodies are found with increased frequency in patients with systemic rheumatic diseases, especially systemic lupus erythematosus. Autoantibodies to beta-2 GP1 are detected in the clinical laboratory by different types of assays including immunoassays and functional coagulation assays.
What is B2 glycoprotein IgM?
B2-Glycoprotein I (IgM) Ab. <20.0 Antibody not detected. ≥20.0 Antibody detected. U/mL. Clinical Significance: Beta-2-Glycoprotein 1 (also known as apolipoprotein H), is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome.
What causes beta-2-glycoprotein?
What is B2 glycoprotein IgG IgM?
What is glycoprotein IgG?
This layer of lipid-proteins is present on the outermost section of most cell membranes and platelets. Beta-2-Glycoprotein 1 IgG/IgM test is an ELISA (Enzyme-linked immune sorbent assay) test that pits the IgG and IgM antibodies to fight against the beta-2-glycoprotein, present in serum and plasma.
Does antiphospholipid syndrome cause fatigue?
Some other people with APS, particularly those who also have lupus, get a rash, joint pains, migraines and become very tired, even when they aren’t pregnant or don’t have blood clots. It is not unusual for people with APS to have periods of tiredness, forgetfulness, confusion and anxiety.
How serious is antiphospholipid syndrome?
Antiphospholipid syndrome can be fatal. Death may occur as a result of dangerous blood clots in the heart, lungs or brain that are caused by antiphospholipid syndrome.
What is the Beta 2 glycoprotein 1 IgM test?
The Beta 2 glycoprotein 1 IgMtestseeks to detect and measure the IgM class of antibodies in the blood. This test has a significant role in the diagnosis and assessment of patients with clear symptoms of Antiphospholipid Antibody Syndrome (APS).
What is the optimal IgA level for beta-2 glycoprotein I?
Beta-2 Glycoprotein I Ab, IgA Optimal Result: 0 – 20 U/mL. Other names for this marker: – β2-Glycoprotein 1 Antibodies, IgA
How are beta-2 glycoprotein 1 (beta-2 GP1) antibodies characterized in antiphospholipid syndrome?
If the blood examination report reveals beta-2 glycoprotein 1 (beta-2 GP1) antibodies more than 40 U/mL for IgM, it points to Antiphospholipid syndrome (APS). Patients that manifest clinical signs of APS can portray reduced levels of beta-2 GP1 antibodies in their blood.
What is anti-β2 glycoprotein-I antibody?
Anti-β2 glycoprotein-I antibody of IgG and/or IgM isotype in serum or plasma (in titer > the 99th percentile)