What is the nanosuspension?
[5] Nanosuspensions are submicron colloidal dispersions of nanosized drug particles stabilized by surfactants. [6] Nanosuspensions consist of the poorly water-soluble drug without any matrix material suspended in dispersion.
How do you make a nanosuspension?
Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification and supercritical fluid techniques.
What is Nano encapsulation?
Nanoencapsulation is defined as the technology of packaging nanoparticles of solid, liquid, or gas, also known as the core or active, within a secondary material, named as the matrix or shell, to form nanocapsules (see Fig.
What is Antisolvent precipitation?
Antisolvent precipitation process is a promising technique to prepare ultrafine drug particles [17], [19]. The basic principle is that the drug is dissolved in a solvent; the solvent solution is then mixed with an antisolvent (in which the drug is insoluble).
What are nanocapsules made of?
A nanocapsule is a nanoscale shell made from a nontoxic polymer. They are vesicular systems made of a polymeric membrane which encapsulates an inner liquid core at the nanoscale.
How do nanocomposites work?
Nanocomposites are materials that incorporate nanosized particles into a matrix of standard material. The result of the addition of nanoparticles is a drastic improvement in properties that can include mechanical strength, toughness and electrical or thermal conductivity.
What is Antisolvent?
Antisolvent is a solvent in which your compound is less soluble. Usually solvent/antisolvent mixture is a good component for obtaining crystals, especially in the case of organic compounds.
What is Antisolvent crystallization?
Anti-solvent crystallization, also known as precipitation, is a widely used technique in the pharmaceutical and fine chemical industry to recover a product from solution in a solvent in which the product has high solubility.
What is a micronizing mill?
Feb 06, 2012. The McCrone micronizing mill is an effective means of reducing sample to sub-micron sizes suitable for x-ray diffraction; x-ray fluorescence; infra-red spectroscopy; and atomic absorption analysis.
What is a nanosuspension?
Nanosuspensions are colloidal dispersions of nanosized drug particles stabilized by surfactants. Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort.
Are nanosuspensions a more cost-effective alternative to liposomes?
Preparation of nanosuspensions were reported to be a more cost effective and technically more simpler alternative than liposomes and other conventional colloidal drug carriers, particularly for poorly soluble drugs and yield a physically more stable product.
What are the advantages of nanosuspension in drug delivery system?
The advantages of Nano suspensions are improved drug dispersibility and drug solubilization, increased therapeutic efficacy and reduced toxicity. Therefore, the present review described about achievements of nanosuspensions in drug delivery system in order to improve the solubility, stability and bioavailability of the drugs.
What are the additives used in nanosuspension?
Nanosuspensions may contain additives such as buffers, salts, polyols, osmogent and cryoprotectant, depending on either the route of administration or the properties of the drug moiety. 7 5. Properties of Nanosuspensions Following are the properties of nanosuspensions