Is Cefotetan a broad-spectrum antibiotic?
As with other broad-spectrum antibiotics, prolonged use of cefotetan may result in overgrowth of nonsusceptible organisms. Careful observation of the patient is essential.
What is the spectrum of erythromycin?
Erythromycin has a similar spectrum of activity to broad-spectrum penicillins and is often used for treating individuals who are allergic to penicillin. It is effective against Gram-positive bacteria and gut anaerobes but has poor activity against H. influenzae.
Does erythromycin have a broad-spectrum?
Erythromycin is a broad-spectrum, macrolide antibiotic with antibacterial activity. Erythromycin diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome.
Does Cefotetan cover anaerobes?
Cefotetan displays a wide spectrum of activity, being effective against both gram-positive and gram-negative aerobes and anaerobes.
What are the clinical applications of cefotetan?
Cefotetan has shown good clinical efficacy in intra-abdominal, obstetric and gynaecological infections, postoperative wound infections, and infections in immunocompromised patients – all of which are often complicated due to their polymicrobial nature or by the presence of anaerobic pathogens.
What is the half life of cefotetan?
Cefotetan is particularly active against Enterobacteriaceae but has little activity against Pseudomonas aeruginosa. An extended plasma elimination half-life of about 3.5 hours, and relatively high achievable serum and tissue levels, enables cefotetan to be administered on a twice daily basis in the treatment of mild to severe infections.
Which macrolide is most active against Actinomyces spp?
Clarithromycin is the most active macrolide against Gram-positive oral cavity anaerobes, including Actinomyces spp., Propionibacterium spp., Lactobacillus spp., and Bifidobacterium dentium. Azithromycin is slightly less active than erythromycin against these species ( 117 ).
What is the mechanism of action of macrolides?
More specifically, macrolides bind to the 50S ribosomal subunit; binding that results in blockade of the translocation process which is needed for the polypeptide chain to grow and elongate. This process is bacteriostatic.