What is intratumoral heterogeneity?
Intratumor heterogeneity (also known as intralesion heterogeneity) refers to distinct tumor cell populations (with different molecular and phenotypical profiles) within the same tumor specimen [1]. Cancer is typically defined as a genetic disease driven by oncogenic mutations.
Is breast cancer a heterogeneous disease?
Breast cancer is a heterogeneous disease and differs greatly among different patients (intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity). Clinical and morphologic intertumor heterogeneity is reflected by staging systems and histopathologic classification of breast cancer.
Is cancer a heterogeneous?
Cancer is a heterogeneous disease. Practically from the moment pathologists first looked at human cancers under the microscope, they saw that differing histologic appearances could define distinct subtypes of cancers from the same primary site of origin.
What is heterogeneous mass in breast?
A term used to describe breast tissue that has large areas of dense fibrous tissue and glandular tissue and also has some fatty tissue. The dense areas of the breast make it harder to find tumors or other changes on a mammogram.
What does intratumoral mean?
Within a tumor
(IN-truh-TOO-mer-ul) Within a tumor.
What do you mean by heterogeneity?
Definition of heterogeneity : the quality or state of consisting of dissimilar or diverse elements : the quality or state of being heterogeneous cultural heterogeneity.
What is a heterogeneous disease?
A heterogeneous medical condition or heterogeneous disease is a medical term referring to a medical condition with several etiologies (root causes), such as hepatitis or diabetes.
How many subtypes of breast cancer are there?
Breast cancer has four primary molecular subtypes, defined in large part by hormone receptors (HR) and other types of proteins involved (or not involved) in each cancer: Luminal A or HR+/HER2- (HR-positive/HER2-negative) Luminal B or HR+/HER2+ (HR-positive/HER2-positive)
What causes cancer heterogeneity?
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability.
Whats is heterogeneity?
What does heterogeneous mass mean?
Heterogeneous refers to a structure with dissimilar components or elements, appearing irregular or variegated. For example, a dermoid cyst has heterogeneous attenuation on CT. It is the antonym for homogeneous, meaning a structure with similar components. Heterogenous refers to a structure having a foreign origin.
What does heterogeneous activity mean?
different in kind; unlike; incongruous. composed of parts of different kinds; having widely dissimilar elements or constituents: The party was attended by a heterogeneous group of artists, politicians, and social climbers.