What is microvillus inclusion?
Microvillus inclusion disease is a condition characterized by chronic, watery, life-threatening diarrhea typically beginning in the first hours to days of life. Rarely, the diarrhea starts around age 3 or 4 months. Food intake increases the frequency of diarrhea.
What is microvillus atrophy?
Microvillus atrophy is caused by an abnormality in the cells in the small intestine that make it impossible for them to absorb any fluid or nutrients from food. The gastrointestinal (GI) tract is a complex organ that extends as a hollow tube from the mouth to the anus.
What is intestinal inclusion?
Summary. Listen. Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life.
How is microvillus inclusion disease diagnosed?
The diagnosis of MVID may be based upon electron microscopy of a tissue sample (biopsy) from the intestine of an ailing child, which depicts microscopic findings of brush border defects in the villus in association with microvillus inclusions (MIs) usually in villus enterocytes characteristic of the disorder.
What is the function of microvillus?
structure and function. …the cell membrane to form microvilli, stable protrusions that resemble tiny bristles. Microvilli on the surface of epithelial cells such as those lining the intestine increase the cell’s surface area and thus facilitate the absorption of ingested food and water molecules.
What is Cytomegalic inclusion disease?
Generalized cytomegalic inclusion disease is a systemic disease, primarily of infancy, characterized by the presence of intranuclear and intracytoplasmic inclusion bodies in enlarged cells of a variety of viscera.
What’s the difference between villi and microvilli?
Villi: The folds form numerous tiny projections which stick out into the open space inside your small intestine (or lumen), and are covered with cells that help absorb nutrients from the food that passes through. Microvilli: The cells on the villi are packed full of tiny hairlike structures called microvilli.
What is enterocytes in the small intestine?
Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells which line the inner surface of the small and large intestines. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase its surface area.
What causes cytomegalovirus inclusion disease?
Cytomegalovirus infection is caused by the human cytomegaloviruses (also known as “salivary gland viruses”). These are a subgroup of infective agents closely related to the herpes group of viruses. Like other herpes viruses, they may remain latent for years in people.
What is cytomegalovirus disease?
Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. This virus. It requires a living cell in which to multiply.