Does chloraseptic cause methemoglobinemia?
Benzocaine (applies to Chloraseptic Sore Throat Lozenges) methemoglobinemia. Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia.
Which local Anaesthetic causes methemoglobinemia?
Four types of local anesthetic have been reported as possibly causing methemoglobinemia: prilocaine, benzocaine, lidocaine, and tetracaine.
How common is methemoglobinemia from Orajel?
The second most common dosage form was oral gel (n=20). Four cases resulted in death, including one infant and three adults. In 36 of the 119 cases (30 percent) the reported methemoglobin level was 30 to 55 percent, with the normal concentration typically around one to two percent.
Can cepacol cause methemoglobinemia?
Cepacol Sore Throat Lozenges (Benzocaine) used in the mouth or throat may cause a rare but life-threatening condition called methemoglobinemia.
What happens if you use too much Chloraseptic spray?
Symptoms of overdose may include: slow/shallow breathing, seizures, irregular heartbeat. Keep all regular medical and lab appointments. Not applicable. Store at room temperature away from light and moisture.
Is Chloraseptic spray safe?
It’s available in a pharmacy without a prescription and comes in different flavors. Chloraseptic Sore Throat Spray (Phenol) is alcohol, sugar, and aspirin free, so it’s pretty safe to use. If you buy the “max” throat spray, it contains an additional medication that forms a soothing film over your throat.
Does lidocaine cause methemoglobinemia?
Methemoglobinemia is a potentially severe complication of lidocaine and benzocaine, especially when used concomitantly. Among the acquired causes of methemoglobinemia, although caine-induced methemoglobinemia is rare, it may have a fatal outcome.
Which drug can cause methemoglobinemia?
Certain drugs are more likely to cause methemoglobinemia than others. These are dapsone, local anesthetics, phenacetin, and antimalarial drugs.
How long does methemoglobinemia take to develop?
The onset of methemoglobinemia is usually within 20 to 60 minutes of drug administration. Normally, 5 g/dL of deoxyhemoglobin (compared with 1.5 g/dL [10%–15%] of methemoglobin) produces noticeable cyanosis.
Does methemoglobinemia resolve on its own?
The condition is benign. There is no effective treatment for people with a congenital form who develop an acquired form. This means that they should not take drugs such as benzocaine and lidocaine. People who acquire methemoglobinemia from medications can completely recover with proper treatment.
How do you know if you have methemoglobinemia?
Diagnosing methemoglobinemia tests to check enzymes. examination of blood color. blood levels of nitrites or other drugs. pulse oximetry to check the saturation of oxygen in your blood.
Who is at risk of methemoglobinemia?
Acquired methemoglobinemia is more frequent in premature infants and infants younger than 4 months, and the following factors may have a role in the higher incidence in this age group: Fetal hemoglobin may oxidize more easily than adult hemoglobin.
What is benzocaine spray methemoglobinemia?
[04-07-2011] The U.S. Food and Drug Administration (FDA) is alerting healthcare professionals that the Agency continues to receive reports of methemoglobinemia, a serious and potentially fatal adverse effect, associated with benzocaine sprays. These sprays are used during medical procedures to numb the mucous membranes of the mouth and throat.
Can benzocaine 20% (Hurricaine) cause methemoglobinemia?
It can be lethal if levels exceed 70%. Benzocaine 20% (Hurricaine) spray, commonly used in endoscopy (EGD) can cause methemoglobinemia. We report our experience. Methods: Two patients out of >1,000 EGDs in 4 yrs developed methemoglobinemia.
Which topical anesthetic sprays are associated with methemoglobinemia?
Many topical anesthetic sprays such as CETACAINE (benzocaine 14%, tetracaine 2%) and HURRICAINE (benzocaine 20%) have been implicated in cases of methemoglobinemia, a serious and sometimes fatal adverse drug reaction.
What is methemoglobinemia and its treatment?
Methemoglobinemia: Treatment. Definition. Methemoglobin (MetHb) is altered state of hemoglobin (Hb) in which the ferrous (Fe2+) irons of heme are oxidized to the ferric (Fe3+) state. The ferric hemes of MetHb are UNABLE to bind oxygen (O2).