Is juvenile granulosa cell tumor malignant?
Juvenile granulosa cell tumor is a rare gynecologic malignancy. We describe a case of this tumor arising in a young woman. Initially assigned to Stage IC, the patient returned 3 months later with metastatic disease. Imaging findings in this case are discussed and pathologic examination confirms the diagnosis.
What is a Thecoma?
Definition. Thecomas are defined as stromal tumors that resemble thecal cells of the developing follicle and that are composed of a minimum (less than 10%) of cells with granulosa cell differentiation. They are only one-third as common as granulosa cell tumors and account for less than 1% of all ovarian tumors.
What is ovarian granulosa?
Ovarian granulosa cell tumor (GCT) is a malignant tumor originating from the sex-cord stromal cells of the ovary. It is an uncommon primary malignant tumor of the ovary and represents 2% to 5% of all ovarian cancers [1].
How are granulosa cell tumors treated?
Surgery is the primary treatment modality for granulosa cell tumors. Advanced stage and presence of residual disease were associated with inferior survival, but only prospective studies can ascertain their definite role.
What causes granulosa cell tumor?
The most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown.
What is a Luteoma?
Luteoma of pregnancy is a rare, benign condition characterized by a tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. It is usually asymptomatic and the diagnosis is generally incidental.
What is a Gonadoblastoma?
(goh-NA-doh-blas-TOH-muh) A rare tumor that is made up of more than one type of cell found in the gonads (testicles and ovaries), including germ cells, stromal cells, and granulosa cells. Gonadoblastomas are usually benign (not cancer), but they may sometimes become malignant (cancer) if not treated.
What is a granulosa cell?
Granulosa cells are a type of cell in your ovaries that produce hormones including estrogen and progesterone. Hormones released from the base of your brain (anterior pituitary) control the numbers and function of granulosa cells.
What do granulosa cells secrete?
The granulosa cells respond to follicle stimulating hormone (FSH) and produce estrogen.
What causes granulosa cell tumors?