What is amodiaquine hydrochloride used for?
Amodiaquine is an aminoquinoline used for the therapy of malaria. Amodiaquine has been linked to severe cases of acute hepatitis which can be fatal, for which reason it is recommended for use only as treatment and not for prophylaxis against malaria.
How does amodiaquine work?
They depress respiration and cause diplopia, dizziness and nausea. The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.
What does amodiaquine contain?
Amodiaquine is a quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position. It has a role as an antimalarial, a non-steroidal anti-inflammatory drug, a drug allergen, a prodrug, an EC 2.1. 1.8 (histamine N-methyltransferase) inhibitor and an anticoronaviral agent.
Does amodiaquine cause itching?
What are the side effects of Amodiaquine? Most Common : Nausea, vomiting, itching, stomach upset and headache. Miscellaneous : Loss of vision, skin rash, muscle pain, loss hearing and graying of hair.
What is the side effects of amodiaquine?
Side effect(s) of Amodiaquine Most Common – Nausea, vomiting, itching, stomach upset and headache. Miscellaneous – Loss of vision, skin rash, muscle pain, loss hearing and graying of hair. Other Precautions : * Avoid excess dosage.
Is amodiaquine same as chloroquine?
Amodiaquine is being used in India for presumptive treatment as an alternative to chloroquine in areas with chloroquine resistant P. falciparum. Keeping in view the toxicity of amodiaquine, studies have been undertaken to evaluate the advantage of the drug over chloroquine in the treatment of P. falciparum malaria.
What is the brand name of amodiaquine?
Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria.
What are the side effects of amodiaquine?
Who is amodiaquine?
Amodiaquine is a synthetic 4-aminoquinoline antimalarial. Its activity is characterized by a schizonticidal action on Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malaria by destroying intraerythrocytic forms.
What is the brand name of Amodiaquine?
Who is Amodiaquine?
What is the generic name for amodiaquine?
What is amodiaquine hydrochloride?
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine -resistant strains,…
How does amodiaquine work as a Plasmodic?
Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites. Amodiaquine is an aminoquinoline used for the therapy of malaria.
What is the half life of amodiaquine 600 mg?
5.2 ± 1.7 (range 0.4 to 5.5) minutes Amodiaquine 600 mg was given by mouth, the apparent terminal half-life of amodiaquine was 5.2 + 1.7 (range 0.4 to 5.5) minutes and the geometric mean of the estimated elimination phase half-lives was 2.1 (range 0.5 to 5.7) hours. WHO; Poisons Information Monographs (PIMs) 030: Amodiaquine.
Is amodiaquine available in the US?
Amodiaquine was first made in 1948. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. While not available in the United States, it is widely available in Africa.