What is tafenoquine used for?
The US Food and Drug Administration (FDA) has approved the drug tafenoquine for 2 indications: Prophylaxis of malaria (Arakoda) Radical cure1 of Plasmodium vivax malaria (Krintafel)
How much does tafenoquine cost?
TAFENOQUINE is used to treat or prevent malaria infections. The lowest GoodRx price for the most common version of Krintafel is around $32.26, 31% off the average retail price of $46.96.
How is tafenoquine administered?
If you are taking tafenoquine (Arakoda) for the prevention of malaria, one dose (2 tablets) is usually taken once a day for 3 days, starting 3 days before traveling to an area where there is malaria. While you are in the area, one dose (2 tablets) is usually taken once a week on the same day of the week.
Is tafenoquine approved?
Uses. Tafenoquine was approved by the US Food and Drug Administration (FDA) on 20 July 2018, for radical cure of Plasmodium vivax malaria (Krintafel™), that indication is part of the portfolio of GSK.
Is Tafenoquine an antibiotic?
Tafenoquine is an antimalarial drug of the 8-aminoquinoline class, a synthetic analog of primaquine (Brueckner et al., 1998). It is a prodrug that requires activation through metabolism by CYP2D6 (Marcsisin et al., 2014).
Is Tafenoquine available in India?
While tafenoquine is claimed to be more effective, it is still not available in India.
How can malaria relapse be prevented?
Currently, primaquine is the only treatment available to prevent the relapse of Plasmodium vivax malaria. However, as per the primaquine label and WHO recommendations, it is administered once daily for 14 days – a regimen that is hard for patients to comply with, meaning that many are not cured.
Who manufactures Tafenoquine?
About tafenoquine Tafenoquine developed by GSK and MMV was first approved by the US Food and Drug Administration for the radical cure of P. vivax malaria in July 2018 for use in adults and adolescents ≥16 years old who are receiving appropriate antimalarial therapy for acute P.
Why is primaquine contraindicated in G6PD deficiency?
Unfortunately, primaquine causes dangerous side effects in certain individuals who are deficient in an enzyme called G6PD, which helps defend red blood cells against stresses. Primaquine damages these cells so that they burst, leading to anaemia.
What is the structure of primaquine?
C15H21N3OPrimaquine / Formula
Why does my malaria keep coming back?
Two types (species) of parasites, Plasmodium vivax and P. ovale, have liver stages and can remain in the body for years without causing sickness. If not treated, these liver stages may reactivate and cause malaria attacks (“relapses”) after months or years without symptoms.
What triggers malaria relapse?
Relapses occur because P. vivax and P. ovale have dormant liver stage parasites (“hypnozoites”) that may reactivate. Treatment to reduce the chance of such relapses is available and should follow treatment of the first attack.