What is a dsDNA test?
The anti-dsDNA (anti-double stranded DNA) antibody test is a blood test that looks for antibodies to double stranded DNA. The anti-dsDNA antibody test is a very specific test for Systemic Lupus Erythematosus (SLE) because Anti-dsDNA antibodies aren’t found in any other autoimmune disorders.
What does positive dsDNA mean?
A positive result for double-stranded DNA (dsDNA) IgG antibodies in the appropriate clinical context is suggestive of systemic lupus erythematosus (SLE).
What is anti-dsDNA normal range?
Reference Range: <30.0 IU/mL Negative 30.0 – 75.0 IU/mL Borderline >75.0 IU/mL Positive Negative is considered normal.
What is negative dsDNA?
Negativity of anti-dsDNA antibody, which is usually considered to be diagnostic of lupus nephritis, poses a diagnostic dilemma short of renal biopsy. Till date only very few cases of non-drug induced lupus nephritis with negative dsDNA antibodies have been reported.
Does positive dsDNA mean lupus?
Anti-double-stranded DNA (dsDNA), in high titer, is nearly specific to lupus. It is usually associated with a homogeneous or peripheral ANA pattern. The antibody is named for its ability to bind to the normal DNA in patients’ cells.
Can you test positive for dsDNA and not have lupus?
Anti-double-stranded DNA (dsDNA) The antibody is named for its ability to bind to the normal DNA in patients’ cells. Patients with this antibody who do not have SLE usually have a similar illness, such as rheumatoid arthritis. Sometimes the test is positive in otherwise well family members of lupus patients.
What is a high level of dsDNA?
A high level of anti-dsDNA in the blood is strongly associated with lupus and is often significantly increased during or just prior to a flare-up. When the anti-dsDNA is positive and the person tested has other clinical signs and symptoms associated with lupus, it means that the person tested likely has lupus.
What is a high amount of anti-dsDNA?
Titer levels for anti-dsDNA antibodies were reported as negative (≤4 IU/ml), indeterminate (5–9 IU/ml), or positive (≥10 IU/ml). Average intra-assay reproducibility rates for a high positive panel and a low positive panel were 2.2% and 3.1%, respectively.
What does dsDNA 1/10 mean?
Double Stranded DNA (dsDNA) antibodies (1:10 or greater) are found in 50-60 percent of systemic lupus erythematosus (SLE), 20-30 percent in Sjögren syndrome, 20-25 percent in mixed connective tissue disease (MCTD), and less than 5 percent in progressive systemic sclerosis (PSS).
Can you have dsDNA and not have lupus?
The anti-dsDNA test is fairly specific for lupus; however, only 65-85% of people with lupus may be positive; that is, a negative anti-dsDNA does not rule out lupus. If a person has a positive ANA, an anti-dsDNA test may be used to distinguish lupus from other autoimmune disorders that have similar signs and symptoms.
What is normal range for dsDNA?
The DS-DNA- Antibody test is essential when the person encounters fatigue, tiredness, weight loss, hair loss, Urine passes out in dark color, Skin sensitivity for light, headache, and fluctuation in mental status. 30.0 – 75.0 IU/mL is the borderline value for antibodies presence. Lesser than 30.0 is the normal status.
What does high anti-DNA(ds) level indicate?
A high level of anti-dsDNA in the blood is strongly associated with lupus and is often significantly increased during or just prior to a flare-up. When the anti-dsDNA is positive and the person tested has other clinical signs and symptoms associated with lupus, it means that the person tested likely has lupus.
What is a positive double stranded DNA test?
Useful For Suggests clinical disorders or settings where the test may be helpful
What is a double stranded DNA test?
Monitoring the progress of lupus