Does Bactrim need renal adjustment?
The double-strength tablet of trimethoprim/sulfamethoxazole (Bactrim, Septra), which is commonly prescribed, should be avoided unless the patient’s creatinine clearance is known to exceed 50 mL per minute; the single-strength tablet of trimethoprim/sulfamethoxazole is preferable.
Is meropenem safe in renal failure?
In summary, meropenem has an excellent safety profile and is therefore suitable for use in elderly and/or renally impaired patients.
What medications need to be renally dosed?
Medications Requiring Renal Dosage Adjustments
- Allopurinol (Zyloprim)
- Lithium (Lithobid)
- Acyclovir (Valtrex)
- Amantadine (Symmetrel)
- Fexofenadine (Allegra)
- Gabapentin (Neurontin)
- Metoclopramide (Reglan)
Which antibiotics are not renally dosed?
There are always some exceptions in the world of infectious diseases, but some antibiotics to put on that “not common to require renal dose adjustment” list includes: oxacillin, nafcillin, moxifloxacin, ceftriaxone, clindamycin, linezolid and tigecycline.
Is Bactrim hard on kidneys?
Bottom Line. Bactrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly.
Does Bactrim lower GFR?
Bactrim inhibits a particular cationic transporter in the proximal convoluted tubule which is also responsible for creatinine secretion. By doing this, serum creatinine elevates without an acutal decrease in GFR.
Is meropenem renally dosed?
Renal Dosing [26-50]: Usual: 1 gram q12h. [10-25]: Usual: 500 mg q12h.
Does meropenem require renal adjustment?
The adult dose should be administered. There is no experience in children with renal impairment. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see sections 6.2, 6.3, and 6.6)….Meropenem 1g powder for solution for injection/infusion.
| Infection | Dose to be administered every 8 hours |
|---|---|
| Management of febrile neutropenic patients | 20 mg/kg |
What antibiotics can you take with kidney disease?
VII. Precautions: Antibiotics
- Antibiotics that require NO renal dose adjustment. Azithromycin.
- Agents to avoid in severe Chronic Kidney Disease. Penicillin G (Myoclonus, Seizures, coma risk)
- Amoxicillin. Reduce to every 24 hours if GFR<10 ml/min.
- Augmentin.
- Cefazolin.
- Cefuroxime.
- Cephalexin.
- Ciprofloxacin.
What drugs are dosed by GFR?
Antihypertensive Agents: Dosing Requirements in Patients with Chronic Kidney Disease
| Drug | Usual dosage* | Dosage adjustment (percentage of usual dosage) based on GFR (mL per minute per 1.73 m2) |
|---|---|---|
| < 10 | ||
| Atenolol (Tenormin) | 5 to 100 mg daily | 25% |
| Bisoprolol (Zebeta)§ | 10 mg daily | 50% |
| Nadolol (Corgard)5 | 40 to 80 mg daily | 25% |
Which antibiotic is least nephrotoxic?
Among these treatment groups, tobramycin was the least nephrotoxic of the aminoglycosides.
Which antibiotics are nephrotoxic?
The potentially nephrotoxic antibiotics in current clinical use are neomycin, kanamycin, paromomycin, bacitracin, the polymyxins (polymyxin B, and colistin), and amphotericin B.